Given that previous reports have shown that a specific inhibitor of SIRT2 abolished the STAT3 signalling pathway21 and have demonstrated the important role of the well-known STAT3 pathway in tumour angiogenesis22,23, we hypothesized that SIRT2 regulates the secretion of VEGFA via the STAT3 signalling pathway. The gene discussed is SIRT2; the disease is neoplasm.