Interestingly, DSCR1 increases the expression of GSK3β in PC-12 cells [38] and nuclear factor-κB-inducing kinase (NIK) induces hyperglycemia by phosphorylating CREB in obesity [39] and DSCR1 stability [40]. The gene discussed is GSK3B; the disease is obesity due to melanocortin 4 receptor deficiency.