The MyD88 L252P (also referred to as L265P) mutation is implicated in almost 100% of Waldenstrom’s macroglobulinemia (WM) cases, 2–10% of chronic lymphocytic leukaemia (CLL) cases, 69% of cutaneous diffuse large B cell lymphoma (DLBCL) cases, and 38% of primary central nervous system lymphoma (PCNSL) cases [39–41]. This evidence concerns the gene MYD88 and B-cell chronic lymphocytic leukemia.