In this study, we observed P/LP variation in the 24 ACMG SF v2.0 cancer genes (specifically, BRCA2, MLH1, MSH2, PMS2, and TP53) in 0.8% of our 982 controls, who, by a mean age of ~ 70 years, had not developed any malignancy. This evidence concerns the gene BRCA2 and cancer.