Also, it has been observed a marked down-regulation of CRC-related pathways such as Wnt/β-catenin, phosphatidylinositol-3-kinase (P3IK)/Akt, nuclear factor-κB (NF-κB), and signal transducer and activators of transcription (STAT)3 [33,67]. The gene discussed is NFKB1; the disease is colorectal carcinoma.