HDAC3 and breast cancer: HDAC3 can also decrease expression of Hypoxia-inducible factor-1 α (HIF-1α) by negative regulation of NF-κB in metastatic breast cancer cells [10] and regulates the signal transducer and activator of transported 3 (Stat3) which inhibits Beclin 1, a prognostic marker and autophagy in non-small cell lung cancer cells [11].