miR-101 epigenetically suppresses the expression of LIM domain only 3 (LMO3) by inhibiting the binding of Upstream stimulatory factor 1 (USF) and Myeloid Zinc Finger 1 (MZF1) to the LMO3 promoter and induces cell apoptosis in U251 glioma cells [155]. This evidence concerns the gene USF1 and central nervous system cancer.