An increased expression of lncRNA TP73-AS1 is associated with poor survival in patients, and the down-regulation of TP73-AS1 inhibited the proliferation and invasion processes together with High-Mobility Group Box 1 (HMGB1) expression, which plays an important role in many diseases including cancer by targeting miR-142 [103,123,124]. The gene discussed is TP73; the disease is cancer.