PVT I, by binding to miR-190a-5p and miR-488-3p, is able to regulate the expression of Myocyte Enhancer Factor 2C (MEF2C) and JAGGED1. It is known that the JAGGED1-NOTCH signaling pathway is critical for glioma proliferation [98]. The gene discussed is MEF2C; the disease is central nervous system cancer.