ATG16L1 and Cowden disease: Recently, GWASs identified several genetic variants, including variants of NOD2 [53,65,66,67,68], ATG16L1 [69,70,71,72,73,74,75,76,77], IRGM [78,79,80,81], and XIAP [82,83,84,85,86,87] linked to the onset of CD.