The multiple logistic regression model was used to determine the significance of the genotype of the SNP as a probable independent risk factor for MetS and found that the 2548AA homozygote genotype of LEP gene carriers had an increased risk for the development of MetS compared with those with the most frequent GG genotype (OR = 3.23; p = 0.035) (Table 3). Here, LEP is linked to metabolic syndrome.