BRAF and acute myeloid leukemia: More recently, Wander et al. also reported a t-AML patient with a BRAF V600E mutation, who was refractory to several induction regimens, yet demonstrated a remarkable response to combined targeted BRAF/MEK therapy (with dabrafenib and trametinib) as evidenced by restoration of normal hematopoiesis, clearance of peripheral blasts, and a significant reduction in marrow leukemic burden with a concordant decrease in the BRAF V600E allelic burden [52].