MAPT and Mental deterioration: Negative correlations were also observed between cognitive decline and tau pathology in anterior putamen (r = −0.455, P = 0.008), insula (r = −0.503, P = 0.002) and NFT Braak stage (r = −0.370, P = 0.031), whereas Aβ burden with NAcc (r = −0.428, P = 0.018), caudate (r = −0.399, P = 0.017), anterior putamen (r = −0.420, P = 0.011), posterior putamen (r = −0.408, P = 0.018) and insula (r = −0.411, P = 0.019).