IL6 and melanoma: However, from the result presented in Fig. 4 showing the individual and combined effects of Box5 and/or IL‐6 Ab on the migration and invasion of HTB63‐R and A375‐R cells, one might speculate that the combined inhibition of these independent components (IL‐6 and WNT5A) has an additive effect on reducing the invasive migration of these BRAFi‐R melanoma cells.