To evaluate the independent and combined effects of IL‐6 and WNT5A signalling on the invasive migration of BRAFi‐R melanoma cells, we first blocked WNT5A or IL‐6 signalling separately in HTB63‐R and A375‐R cells by using either Box5 or an IL‐6 Ab. The gene discussed is WNT5A; the disease is melanoma.