Since IL‐6 and WNT5A signalling independently promoted invasive migration and their combined inhibition more effectively reduced the migration and invasion of HTB63‐R and A375‐R melanoma cells, we speculated that the simultaneous inhibition of these two signalling pathways decreased the invasive migration via altered downstream signalling and modulation of the actin cytoskeleton. Here, WNT5A is linked to melanoma.