However, we did not observe a significant reduction in Rac1‐GTPase activity in HTB63‐R cells treated with the combination of IL‐6 Ab and Box5 (Fig. S5B), arguing against an essential role of Rac1 in the IL‐6‐ and WNT5A‐dependent invasive migration of BRAFi‐R melanoma cells. The gene discussed is RAC1; the disease is melanoma.