We observed that TC and CC haplotypes for rs1569061 syntaxin 1A gene and the 33-bp promoter region of the synaptotagmin XI gene could be risk factors for the development of MS [OR (95% CI) 1.686 (1.049-2.710) and 1.588 (1.041-2.420), p=0.012, respectively]. The gene discussed is STX1A; the disease is myeloid sarcoma.