Del allele of VAMP2 gene was observed 1.688 (range 1.183-2.407) times more frequently in patients with MS (p=0.004); similarly, the C allele of synaptotagmin XI gene was observed more frequently in patients with MS [OR (95% CI) 1.711 (1.238-2.363), p=0.001]. This evidence concerns the gene VAMP2 and myeloid sarcoma.