Loss of UTY is linked to increased cell proliferation in urothelial bladder cell lines.28 Its X‐chromosome homolog (UTX, also known as KDM6A) is a demethylase of lysine 27 on histone 3 (H3K27), which is linked to dysregulated squamous cell differentiation in HNSCC cell lines29; UTY may share this enzymatic activity, albeit at a reduced level.30 Loss of UTY has also recently been implicated in both myeloid malignancies and pancreatic cancer via demethylase‐independent mechanisms.31, 32 There is also other experimental evidence to support the tumor suppressive effects of the Y chromosome. Here, UTY is linked to head and neck squamous cell carcinoma.