TP53 and head and neck squamous cell carcinoma: We found that for HPV‐negative male HNSCC, there was no association between the Y chromosome index and evidence of TP53 mutation, whereas for HPV‐positive male HNSCC, there was a statistically significant difference between mutated and nonmutated cases, with the latter having lower levels of LoY (Figure 5A,B, Wilcoxon test P = 0.60 and 0.006, respectively).