TP53 and head and neck squamous cell carcinoma: However, in contrast to the LoY results, we found that HPV‐negative male HNSCC with evidence of TP53 mutation was significantly more aneuploid than that without evidence of mutation, whereas the difference for HPV‐positive male HNSCC was not statistically significant (Figure 5C,D, Wilcoxon P < 0.0001 and P = 0.11, respectively).