These observations are in keeping with the findings of Davoli et al, who showed that across 12 human cancers, including HNSCC, highly aneuploid tumors are depleted for the expression of markers of cytotoxic infiltrating immune cells, especially CD8+ T cells.50 Furthermore, their analysis of data from two clinical trials of immune checkpoint blockade therapy in metastatic melanoma revealed that tumor aneuploidy inversely correlated with patient survival. Here, CD8A is linked to metastatic melanoma.