Furthermore, it has been shown that DNMT3A is the most frequently mutated gene in clonal hematopoiesis of the elderly and this was linked to a higher risk for hematological malignancies—indicating that aberrations in DNMT3A play a central role for clonal hematopoiesis (Genovese et al, 2014; Jaiswal et al, 2014; Xie et al, 2014). Here, DNMT3A is linked to hematologic disorder.