XIAP and cancer: The downregulation NFκB and its downstream targets such as survivin, BCL-XL (B-cell lymphoma-extra large), XIAP (X-linked inhibitor of apoptosis protein) and CIAP (Cellular inhibitor of apoptosis protein), by 3,3-diindolylmethane (DIM) was able to potentiated the efficacy of different anti-cancer drugs in vivo and in vitro [51, 52].