IFNG and psoriasis: However, inhibition of IFN-γ-dependent antiproliferative effects on keratinocytes might not be strategic in a hyperproliferative disorders, such as psoriasis, although IFN-γ can induce massive proliferation of psoriatic stem cells, and its injection into prelesional psoriatic skin causes epidermal hyperplasia and plaque development [31, 32].