In addition, APS can significantly rescue the cardiac dysfunction and the abnormal hematodynamics in several kinds of diabetic model mice with cardiomyopathy, including STZ-induced diabetic mice with type 1 diabetes [17], NOD mice with type 1 diabetes DM [18], db/db mice with type 2 diabetes [19], and MHC-PPAR α mice with myocardial lipotoxicity [20]. Here, HLA-C is linked to type 1 diabetes mellitus.