The incubation of NAT, ATD, and ATAT with the proinflammatory cytokine TNF-α leads to the changes in redox state of mitochondria and activation of a number of the measured factors of inflammation only in tissues where the reprogramming of metabolism has already occurred under the influence of tumor, in ATAT and to a lesser degree in ATD. This evidence concerns the gene BRD2 and neoplasm.