The distribution of genotypes of most obesity-predisposing SNPs was concordant with the Hardy-Weinberg equilibrium principle, except for rs1386835 (PPARG), rs17782313 (MC4R), rs2287019 (QPCTL), and rs3813929 (HTR2C), as shown in Supplementary Table 1. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.