Interestingly, proteomic analysis of BALF revealed that CF ferrets at birth show significant differences as compared with non-CF newborns in liver X receptor/retinoid X receptor (LXR/RXR), eukaryotic initiation factor 2 (eIF2), and mammalian target of rapamycin (mTOR) signaling pathways [110], all regulating inflammatory responses and interacting with the NF-κB pathway. The gene discussed is NFKB1; the disease is cystic fibrosis.