In one study, infected CF cells (IB3 cell line) overexpressed proinflammatory mediators such as cytokines, chemokines, and growth factors but underexpressed protease inhibitors, compared to control cells (S9 cell line, that is, IB3 cells transduced with a CFTR-expressing adenovirus) [72]. The gene discussed is CFTR; the disease is cystic fibrosis.