In contrast, Figure 2 shows that, compared to the aortic valve disease patients with HF, the MR patients with HF had significantly upregulated expression of MAS1 expression (fold change: 189.18, upregulation, P = 0.016 by univariate analysis (Figure 2); P = 0.003 with adjustment for plasma angiotensin II concentration and P = 0.007 with adjustment for left atrial size by analysis of covariance) in the left atrium. This evidence concerns the gene MAS1 and aortic valve disorder.