Compared to normal controls, the aortic valve disease patients had significantly downregulated expressions of ACE (fold change: 0.21, downregulation), ACE2 (fold change: 0.03, downregulation), AT1 (fold change: 0.32, downregulation), ENPEP (fold change: 0.44, downregulation), THOP1 (fold change: 0.57, downregulation), NLN (fold change: 0.43, downregulation), ANPEP (fold change: 0.16, downregulation), CTSG (fold change: 0.37, downregulation), LNPEP (fold change: 0.57, downregulation), MME (fold change: 0.04, downregulation), and CPA3 (fold change: 0.16, downregulation) in the left atrium. The gene discussed is THOP1; the disease is aortic valve disorder.