The endogenous antioxidant systems are unbalanced and produced large amounts of free radicals, leading to the peroxidation of lipid, protein and nucleic acid, and the biochemical alteration (SOD ↓, GSH-Px ↓, and MDA↑), and further led to BBB disruption with secondary vasogenic edema, activation of apoptosis, and brain infarction [47, 48]. This evidence concerns the gene SOD1 and brain infarction.