These studies have suggested direct inhibition of cell growth/proliferation, migration, tumor angiogenesis, and IL-17 production, alongside with enhancement of NK cell responses, antibody-dependent cell-mediated cytotoxicity (ADCC), generation of myeloid progenitor cells, promoting M1 macrophage differentiation, and most importantly activation and promotion of tumor specific cytotoxic T cell responses as means of antitumor mechanisms by IL-27 [5–7, 20]. Here, IL27 is linked to neoplasm.