So, collectively our study and Hendricks's group showed that CD8+ T cells in C57BL/6 mice recognize various HSV-1 epitopes, especially gK but this is in contrast to human TG study in which it was indicated that the human TG is an immunocompetent environment for both CD4+ and CD8+ T cell recognition of diverse HSV-1 proteins expressed during latent infection (89). The gene discussed is CD8A; the disease is disease arising from reactivation of latent virus.