More importantly, anti-Ro60+ SSc patients showed a distinct, previously unrecognized epitopic pattern, characterized by broad recognition of Ro52 epitopes (including Ro52-1, Ro52-2, Ro52-4, and Ro52-5) compared to anti-Ro60- SSc patients where reactivity by large is restricted to Ro52-2. Here, TRIM21 is linked to systemic sclerosis.