Although the pro-inflammatory role of LBP toward Gram-positive ligands has been well-established (9, 10), no correlation was found for LBP with either BPI (r = 0.413, p = 0.161; Figure 1C) or TNFα (r = 0.115, p = 0.709) and IL-6 levels (r = 0.407 and p = 0.106; Figure 1D) in S. pneumoniae meningitis. This evidence concerns the gene TNF and meningitis.