Liver biopsies from woodchucks with CH also had significantly greater transcriptional levels of TLR2 (P < 0.05), TLR4 (P < 0.05), TLR6 (P < 0.05), TLR7 (P < 0.05), and TLR8 (P < 0.05) in relation to the SLAH/SOI stage. The gene discussed is TLR4; the disease is cyclic hematopoiesis.