SCN5A and familial dilated cardiomyopathy: Additionally, mutations in genes encoding cytoskeletal, sarcomere, and nuclear envelope proteins are known to account for up to 35% of all DCM cases (Weintraub et al., 2017); mutations in the LMNA, EMD, or SCN5A gene may trigger supraventricular arrhythmia and conduction disease (Lakdawala and Givertz, 2010).