A positive expression of PD-L1-specific mRNA was detected in all investigated melanoma cells, and it was up-regulated (FC ≥ 2) with a higher frequency in melanoma cells treated with guadecitabine (50%, 7/14) or DAC (50%, 7/14), compared to AZA (21.4%, 3/14) (Figure 3D). Here, CD274 is linked to melanoma.