Exposure to chronic stress procedures in adulthood such as CMS or chronic social defeat, produces significant behavioral deficits across a range of rodent tasks relevant to depression and anxiety including the FST, sucrose preference, social interaction, novelty suppressed feeding and other anxiety-like tests (Yang et al., 2008, 2014; Meng et al., 2011; Cui et al., 2014; Lim et al., 2015; Febbraro et al., 2017; Jacinto et al., 2017; Berger et al., 2018; Zhang H. et al., 2018; Zhang S. et al., 2018), which are attenuated by inactivation of the LHb. Here, LHB is linked to depressive symptom measurement.