KCNJ10 and viral infectious disease: Moreover, a gain of function of Kir4.1, using viral infection (AAV-GFAP:Kir4.1) of the astrocytes in the LHb bilaterally in mice, produced greater hyperpolarization of astrocytes and glia, elevated the percentage of bursting neurons and robustly enhanced immobility levels in the FST and significant reductions in sucrose drinking 21 days post administration.