EGFR and central nervous system cancer: Soon thereafter, Al-Nedawi et al. found EVs derived from gliomas could deliver an oncogenic form of EGFR (epidermal growth factor receptor), EGFRvIII [4], and further showed that EVs released by A431, A549 and DLD1 cancer cell lines could transfer EGFR to induce angiogenesis in human umbilical vein endothelial cells (HUVECs) [5].