XDH and Schnyder corneal dystrophy: Aslan and colleagues demonstrated that ischemia/reperfusion injury in SCD mice resulted in release of XDH from the liver into the circulation, rapid conversion to XO via plasma proteases, immobilization on endothelial GAGs, and represented a major source of O2•- and H2O2 in the vascular compartment [12], as depicted in Fig. 2.