Among CMML patients, a decrease of Alu sequences methylation was observed in those harboring the main SRSF2 hotspot compared to patients without this mutation (p < 0.05, Fig. 5), whereas no significant difference was observed according to the presence of mutations in ASXL1 exon 12 (data not shown). This evidence concerns the gene SRSF2 and chronic myelomonocytic leukemia.