Furthermore, in 2018 Picard et al. reported that polymorphism rs2269657 of the SREBF2 gene, which codes for the protein sterol regulatory element-binding protein-2 (SREBP-2), the master transcription factor regulating cholesterol biosynthesis, showed significant dual association with late-onset AD pathological biomarkers and gene expression levels [5]. The gene discussed is SREBF2; the disease is Alzheimer disease.