In the brain, glucocorticoids target the amygdala‐prefrontal fear circuit via GR.122, 151 For example, central amygdala GR activation increases the expression of CRH and promotes fear‐motivated behaviour.152, 153, 154 The action of glucocorticoids on the different phases of information processing can therefore be exploited for better understanding of the mechanistic underpinning of trauma‐related vulnerability, which may precipitate PTSD symptoms in some individuals (Box 4). Here, NR3C1 is linked to post-traumatic stress disorder.