Studies using high doses of glucocorticoids in emergency room settings showed a beneficial effect in preventing PTSD.174, 175 Cortisol also was effective in treatment of phobias in exposure‐based therapy.176 Why some of these treatment schedules were effective, even beyond the context of the fearful experience might be explained by the remarkable capacity of glucocorticoid receptor modulation to reset the stress system.145. Here, NR3C1 is linked to post-traumatic stress disorder.