Simultaneously, to validate the relationship of CUL1 with EZH2, we used the starBase v3.0 project (http://starbase.sysu.edu.cn/panCancer.php) including the gene expression data of 1104 TCGA breast invasive carcinomas and found CUL1 expression levels were significantly positively correlated with EZH2 expressions (r = 0.518, P < 0.001; Fig. 6c). Here, EZH2 is linked to invasive breast carcinoma.