ZNF132 and esophageal squamous cell carcinoma: The expression-methylation regression analysis in clinical samples shows that gene expression of ZNF132 was significantly negatively correlated with DNA methylation level in cancer clinical samples (P = 0.00284) (Fig. 2a), indicating that the expression profile of ZNF132 in ESCC tissues was altered as a consequence of its promoter hypermethylation in ESCC patients.