In addition, the change of SOD, an indicator of antioxidant, was lower in both NI/R and DI/R groups, especially in DI/R group, and MDA, as an indicator of oxidative stress that was higher in both NI/R and DI/R groups, especially in DI/R group, we speculated that all the above effects are caused by enhanced oxidative stress and diabetes further aggravated it on the basis of I/R injury. The gene discussed is SOD1; the disease is diabetes mellitus.