It is worthwhile noting that EMC4 depletion did not destabilise other subunits but did preclude maturation of SQS (Fig. S5J,K) and other TMD-containing proteins (Shurtleff et al., 2018), and also suppressed flavivirus infection (Savidis et al., 2016), reflecting an important role in EMC functionality. The gene discussed is EMC4; the disease is Flavivirus Infections.