In this study, we investigated the following concerns: (1) whether PAP and TRPV1 that are colocalized in the same cholesterol-rich microdomain modulate antinociception and nociceptive transduction and (2) the consequences of disrupting the integrity of a microdomain containing PAP and TRPV1 in RTX neuropathy. This evidence concerns the gene TRPV1 and neuropathy.