For example, various levels of knockdown in Fkrp – a glycosyltransferase critical for matriglycan synthesis – mimic the broad clinical variability seen in α-dystroglycanopathies (Chan et al., 2010; Blaeser et al., 2013). Here, FKRP is linked to neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan.