Daily basal insulin dose tended to be lower in CHI patients with diabetes within the first treatment year (6.3 IE [4–10] vs. 8.4 IE [5–14] in patients with T1DM, p = 0.12), a trend that reached significance as diabetes progressed (16 IE [7.7–24] vs. 23.2 IE [15.2–31.1] in patients with T1DM, p = 0.02 at follow-up) (Fig. 6c). This evidence concerns the gene INS and diabetes mellitus.