Data on diabetes management, insulin requirements, carbohydrate intake, glycaemic control (HbA1c level), and C-peptide secretion were available for up to 27 of these patients from the first year after manifestation (hereafter specified as “diabetes onset” data), and for up to 42 of these patients from the most recent treatment year (hereafter specified as “follow-up” data). This evidence concerns the gene INS and diabetes mellitus.