KRAS and colorectal cancer: Of note, G12 V together with T35S and V45E are most widely studied mutation sites of Ras. As reported by Catalogue Of Somatic Mutations In Cancer (COSMIC), the incidence of K-Ras point mutation in human cancers is approximately 30%, with pancreatic cancer accounting for 90%, colorectal cancer for 45%, and non-small cell lung cancer for 35% (https://cancer.sanger.ac.uk/cosmic).