Besides, significant association between AKT1 expression and IFN λ3 was observed expression in both ATLL and HAM/TSP patients, thus this finding indicates high expression of AKT1 in HTLV-1 infected cell may induce high IFNλ3 mRNA expression in ATLL and HAM/TSP patients. The gene discussed is AKT1; the disease is tropical spastic paraparesis.