At 48 h post-transfection with the Novel-miRNA-25 mimic, AMPD2 protein was significantly decreased in HEK293T cells transfected with Novel-miRNA-25 mimic compared with levels in cells transfected with the internal control (P < 0.05, Fig. 5d), and the expression of AMPD2 protein was significantly decreased in PBMCs of SLE patients compared with that in PBMCs from HCs (Fig. 5e). Here, AMPD2 is linked to systemic lupus erythematosus.