APOE and dementia: As demonstrated in Additional file 1: Table S4 and Additional file 2: Figure S1, GJA1 expression is more significantly associated with clinical dementia rating (CDR) in the group with AOD > 85 than that with AOD < 85, in females than males, and in the group with APOE E33 than that with E34 or E23, across four brain regions in the MSBB cohort, suggesting that age, sex and APOE genotypes impact the association of GJA1 expression with clinical and pathological traits.