Among the 19 brain cortex regions investigated in the MSBB AD microarray data, GJA1 expression in six cortex regions including BM10 (frontal pole), BM20 (inferior temporal gyrus), BM21 (middle temporal gyrus), BM32 (anterior cingulate), BM36 (parahippocampal gyrus) and BM46 (dorsolateral prefrontal cortex) was significantly correlated with at least three AD neuropathological traits (Fig. 2b, and Additional file 1: Table S2). The gene discussed is GJA1; the disease is Alzheimer disease.