Similarly, using a network-based pharmacological analysis, mulberry extracts have been proposed to regulate TNF-α, PPARγ, glycogen synthase kinase-3 beta (GSK3B), insulin receptor substrate 1 (IRS1), interleukin 6 (IL-6) and other proteins involved in diabetes and obesity associated complications [132]. This evidence concerns the gene IRS1 and obesity due to melanocortin 4 receptor deficiency.