EHMT2 and familial pancreatic carcinoma: In addition, we previously demonstrated that euchromatic histone lysine methyltransferase 2 (EHMT2), a H3K9 methyltransferase, induces autocrine IL-8/CXCR1/2 stimulation in pancreatic cancer cells and paracrine activation of pancreatic stellate cells (PSCs) to increase GEM resistance.