PRNP and Parkinson disease: Combined computational and experimental studies on the structural impact of Cu2+ binding and disease-related mutations at the N-term_HuPrPC, such as those on copper(II)-alpha-synuclein—an intrinsically disordered protein undergoing fibril formation in Parkinson’s disease [118]—could advance dramatically our understanding of the functional role of Cu2+-PrPC interactions in health and disease.